CRISPR-induced exon skipping is dependent on premature termination codon mutations

CRISPR-induced exon skipping is dependent on premature termination codon mutations

Abstract In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in prema...

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Bibliographic Details
Main Authors: Tingting Sui, Yuning Song, Zhiquan Liu, Mao Chen, Jichao Deng, Yuanyuan Xu, Liangxue Lai, Zhanjun Li
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Genome Biology
Subjects:
Exon skipping
PTC
CRISPR/Cas9
Rabbits
Online Access:http://link.springer.com/article/10.1186/s13059-018-1532-z

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