Problems in Structural and Functional Genomics in Critical States

• Main Authors: V. V. Moroz, L. M. Tuchina, G. G. Poroshenko
• Format: Article
• Language: Russian
• Published: Russian Academy of Medical Sciences 2005-08-01
• Series: Obŝaâ Reanimatologiâ
• Online Access: https://www.reanimatology.com/rmt/article/view/1250

Genetic methods are being increasingly used to understand the pathogenesis of critical states. At present there are two levels at which genetic studies are conducted. The first level (more traditional) is designated as structural genomics. At this level, investigators clarify what gene is involved in the development of the given pathological process or what its structural regions are damaged. Here both cytogenetic and molecular genetic studies are performed. The former studies are aimed at searching for chromosomal structural changes in the given individual, the latter examine structural disturbances in his/her genes and their products and his/her capacity for healing (reparation) of such lesions. The second level is generally called functional genomics. At this level, investigators elucidate a more and more increasing number of genes and their products involved in the pathogenesis of sepsis, acute lung lesions, intravascular coagulation, and other manifestations of critical states. There have been recently more and more publications where the pathogenetic mechanisms of critical states are analyzed, by applying the methods of functional genetics.