Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidi...

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Main Authors:	Hoang Le Tuan Anh, Nguyen Thi Cuc, Bui Huu Tai, Pham Hai Yen, Nguyen Xuan Nhiem, Do Thi Thao, Nguyen Hoai Nam, Chau Van Minh, Phan Van Kiem, Young Ho Kim
Format:	Article
Language:	English
Published:	MDPI AG 2015-01-01
Series:	Molecules
Subjects:	anti-cancer agent chromonylthiazolidine Paeonia lactiflora paeonol selective cytotoxicity semi-synthesis
Online Access:	http://www.mdpi.com/1420-3049/20/1/1151

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spelling	doaj-2272654a54b24e74b0b6f3e25c04c7622020-11-25T01:28:24ZengMDPI AGMolecules1420-30492015-01-012011151116010.3390/molecules20011151molecules20011151Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell LinesHoang Le Tuan Anh0Nguyen Thi Cuc1Bui Huu Tai2Pham Hai Yen3Nguyen Xuan Nhiem4Do Thi Thao5Nguyen Hoai Nam6Chau Van Minh7Phan Van Kiem8Young Ho Kim9Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, VietnamCollege of Pharmacy, Chungnam National University, Daejeon 305-764, KoreaNine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents.http://www.mdpi.com/1420-3049/20/1/1151anti-cancer agentchromonylthiazolidinePaeonia lactiflorapaeonolselective cytotoxicitysemi-synthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hoang Le Tuan Anh Nguyen Thi Cuc Bui Huu Tai Pham Hai Yen Nguyen Xuan Nhiem Do Thi Thao Nguyen Hoai Nam Chau Van Minh Phan Van Kiem Young Ho Kim
spellingShingle	Hoang Le Tuan Anh Nguyen Thi Cuc Bui Huu Tai Pham Hai Yen Nguyen Xuan Nhiem Do Thi Thao Nguyen Hoai Nam Chau Van Minh Phan Van Kiem Young Ho Kim Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines Molecules anti-cancer agent chromonylthiazolidine Paeonia lactiflora paeonol selective cytotoxicity semi-synthesis
author_facet	Hoang Le Tuan Anh Nguyen Thi Cuc Bui Huu Tai Pham Hai Yen Nguyen Xuan Nhiem Do Thi Thao Nguyen Hoai Nam Chau Van Minh Phan Van Kiem Young Ho Kim
author_sort	Hoang Le Tuan Anh
title	Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_short	Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_full	Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_fullStr	Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_full_unstemmed	Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_sort	synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-01-01
description	Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents.
topic	anti-cancer agent chromonylthiazolidine Paeonia lactiflora paeonol selective cytotoxicity semi-synthesis
url	http://www.mdpi.com/1420-3049/20/1/1151
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Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines

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