Design and Synthesis of New Benzophenone Derivatives with In Vivo Anti-Inflammatory Activity through Dual Inhibition of Edema and Neutrophil Recruitment

Design and Synthesis of New Benzophenone Derivatives with In Vivo Anti-Inflammatory Activity through Dual Inhibition of Edema and Neutrophil Recruitment

A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, ch...

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Bibliographic Details
Main Authors: Jaqueline P. Januario, Thiago B. de Souza, Stefânia N. Lavorato, Tatiane C. S. Maiolini, Olívia S. Domingos, João L. Baldim, Laís R. S. Folquitto, Marisi G. Soares, Daniela A. Chagas-Paula, Danielle F. Dias, Marcelo H. dos Santos
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
hydrazinothiazole
tiosemicarbazone
molecular docking
structure activity relationship
ear edema
Online Access:http://www.mdpi.com/1420-3049/23/8/1859

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