Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversi...

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Bibliographic Details
Main Authors: Tessianna A. Misko, Yi-Ting Liu, Michael E. Harris, Nancy L. Oleinick, John Pink, Hsueh-Yun Lee, Chris G. Dealwis
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
ribonucleotide reductase
cancer
inhibitor
pancreatic
phosphate-binding
Online Access:http://dx.doi.org/10.1080/14756366.2018.1545226

Internet

http://dx.doi.org/10.1080/14756366.2018.1545226

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