Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease

Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease

The expression of major histocompatibility complex class I (MHC-I), a key antigen-presenting protein, can be induced in dopaminergic neurons in the substantia nigra, thus indicating its possible involvement in the occurrence and development of Parkinson's disease. However, it remains unclear wh...

Full description

Bibliographic Details
Main Authors: Bao-Yan Wang, Yong-Yi Ye, Chen Qian, Hong-Bo Zhang, Heng-Xu Mao, Long-Ping Yao, Xiang Sun, Guo-Hui Lu, Shi-Zhong Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
antigen presentation; autoimmune; cd8+ t cell; dopaminergic neuron; major histocompatibility complex class i; mitochondria; neuroinflammation; oxidative stress; parkinson's disease; pink1
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=12;spage=2521;epage=2527;aulast=Wang

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=12;spage=2521;epage=2527;aulast=Wang

Similar Items