Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry

Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry

Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase spindle migration and oocyte division asymmet...

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Bibliographic Details
Main Authors: Zhe Wei, Jessica Greaney, Wei-Guo Nicholas Loh, Hayden Anthony Homer
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17088-6
Description
Summary:Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase spindle migration and oocyte division asymmetry by controlling spindle length.
ISSN:2041-1723

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