| Summary: | The purpose of this commentary is to investigate the pathophysiological
mechanisms underlying hypersexuality and its manifestation in neurological
diseases through a meta-analysis. Studies were identified by searching on PubMed, Web of Science and
Cochrane databases. All results of each database between 2014 and 2020 were
evaluated for possible inclusion. After an accurate revision of complete manuscripts,
forty articles satisfied the inclusion/exclusion criteria. Data from our meta-analysis indicated hypersexuality to be a frequent sexual disorder in patients with neurological
disorders, especially neurodegenerative ones. Hypersexuality could negatively affect a
patient’s management and outcomes. This commentary discusses studies that are often
incomplete for evaluation measures or sample selection. In our opinion, it is
necessary to consider hypersexuality with particular attention, so more extensive sample
studies are needed to find the most appropriate treatment to improve the quality
of life for both the patient and the caregiver.
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