<it>(R)</it>-[<sup>11</sup>C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

<it>(R)</it>-[<sup>11</sup>C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

<p>Abstract</p> <p>Background</p> <p>Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by ind...

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Bibliographic Details
Main Authors: Lammertsma Adriaan A, Huisman Marc C, Windhorst Albert D, Molthoff Carla FM, Luurtsema Gert, Syvänen Stina, Voskuyl Rob A, de Lange Elizabeth C
Format: Article
Language:English
Published: BMC 2011-01-01
Series:BMC Medical Imaging
Online Access:http://www.biomedcentral.com/1471-2342/11/1

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