d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors

d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors

A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers. Two all d-amino acid pseudo-peptides, SGB1 and SGD1, were designed to stop the aggregation. Molecular dynamics (MD) simulation...

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Bibliographic Details
Main Authors: Banafsheh Mehrazma, Stanley Opare, Anahit Petoyan, Arvi Rauk
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
Alzheimer’s
amyloid-beta
inhibitors
d-amino acids
molecular dynamics
umbrella sampling
Online Access:http://www.mdpi.com/1420-3049/23/9/2387

Internet

http://www.mdpi.com/1420-3049/23/9/2387

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