Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I.

Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I.

Viral infection of mammalian cells triggers the innate immune response through non-self recognition of pathogen associated molecular patterns (PAMPs) in viral nucleic acid. Accurate PAMP discrimination is essential to avoid self recognition that can generate autoimmunity, and therefore should be fac...

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Bibliographic Details
Main Authors: Gretja Schnell, Yueh-Ming Loo, Joseph Marcotrigiano, Michael Gale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3410852?pdf=render

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