Losartan Preserves Erectile Function by Suppression of Apoptosis and Fibrosis of Corpus Cavernosum and Corporal Veno-Occlusive Dysfunction in Diabetic Rats

Losartan Preserves Erectile Function by Suppression of Apoptosis and Fibrosis of Corpus Cavernosum and Corporal Veno-Occlusive Dysfunction in Diabetic Rats

Background/Aims: Transforming growth factor-β1 (TGF-β1) plays important roles in penile corporal fibrosis and veno-occlusive dysfunction (CVOD). Angiotensin II (Ang II) is critically involved in erectile dysfunction, and blocking of Ang II is more important than inhibition of TGF-β in non-penile tis...

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Bibliographic Details
Main Authors: Wen Ji Li, Mingxi Xu, Meng Gu, Da-chao Zheng, Jianhua Guo, Zhikang Cai, Zhong Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Angiotensin II
Apoptosis
Diabetes
Erectile dysfunction
Fibrosis
Veno-occlusive dysfunction
Online Access:http://www.karger.com/Article/FullText/477388

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