HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

Abstract Background Emerging evidence suggests that epithelial mesenchymal transition (EMT) and epigenetic mechanisms promote metastasis. Histone deacetylases (HDACs) and noncoding RNAs (ncRNAs) are important epigenetic regulators. Here, we elucidated a novel role of histone deacetylase 2 (HDAC2) in...

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Bibliographic Details
Main Authors: Xue-ting Hu, Wei Xing, Rong-sen Zhao, Yan Tan, Xiao-feng Wu, Luo-quan Ao, Zhan Li, Meng-wei Yao, Mu Yuan, Wei Guo, Shang-ze Li, Jian Yu, Xiang Ao, Xiang Xu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CRC
Metastasis
HDAC2
H19
EMT
Online Access:https://doi.org/10.1186/s13046-020-01783-9

Internet

https://doi.org/10.1186/s13046-020-01783-9

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