Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).

Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).

Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the neces...

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Main Author: Amy B Rosenfeld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3177865?pdf=render
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spelling doaj-220ace1f747d4d639f008281f77c4b6c2020-11-25T00:48:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2511610.1371/journal.pone.0025116Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).Amy B RosenfeldControlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas(V12) can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas(V12). These observations indicate that Paip2 is able to function as a tumor suppressor.http://europepmc.org/articles/PMC3177865?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Amy B Rosenfeld
spellingShingle Amy B Rosenfeld
Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
PLoS ONE
author_facet Amy B Rosenfeld
author_sort Amy B Rosenfeld
title Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
title_short Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
title_full Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
title_fullStr Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
title_full_unstemmed Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
title_sort suppression of cellular transformation by poly (a) binding protein interacting protein 2 (paip2).
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas(V12) can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas(V12). These observations indicate that Paip2 is able to function as a tumor suppressor.
url http://europepmc.org/articles/PMC3177865?pdf=render
work_keys_str_mv AT amybrosenfeld suppressionofcellulartransformationbypolyabindingproteininteractingprotein2paip2
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