Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
To study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics w...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5898739?pdf=render |
id |
doaj-220998a55f2d4113981efc5ef7b1c90e |
---|---|
record_format |
Article |
spelling |
doaj-220998a55f2d4113981efc5ef7b1c90e2020-11-25T01:46:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019570310.1371/journal.pone.0195703Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.Yaoqi GeYuejiao ZhongGuozhong JiQianling LuXinyu DaiZhirui GuoPeng ZhangGang PengKangzhen ZhangYuntao LiTo study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe3O4@Au-C225 composite targeted MNPs on U251 cells in vitro were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe3O4@Au-C225 composite targeted MNPs by MRI.The self-prepared Fe3O4@Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe3O4@Au-C225 composite targeted MNPs were prepared successfully. Fe3O4@Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251 in vitro; Fe3O4@Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice in vivo, and can be traced by MRI.The Fe3O4@Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma in vivo.http://europepmc.org/articles/PMC5898739?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yaoqi Ge Yuejiao Zhong Guozhong Ji Qianling Lu Xinyu Dai Zhirui Guo Peng Zhang Gang Peng Kangzhen Zhang Yuntao Li |
spellingShingle |
Yaoqi Ge Yuejiao Zhong Guozhong Ji Qianling Lu Xinyu Dai Zhirui Guo Peng Zhang Gang Peng Kangzhen Zhang Yuntao Li Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. PLoS ONE |
author_facet |
Yaoqi Ge Yuejiao Zhong Guozhong Ji Qianling Lu Xinyu Dai Zhirui Guo Peng Zhang Gang Peng Kangzhen Zhang Yuntao Li |
author_sort |
Yaoqi Ge |
title |
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. |
title_short |
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. |
title_full |
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. |
title_fullStr |
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. |
title_full_unstemmed |
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma. |
title_sort |
preparation and characterization of fe3o4@au-c225 composite targeted nanoparticles for mri of human glioma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
To study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe3O4@Au-C225 composite targeted MNPs on U251 cells in vitro were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe3O4@Au-C225 composite targeted MNPs by MRI.The self-prepared Fe3O4@Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe3O4@Au-C225 composite targeted MNPs were prepared successfully. Fe3O4@Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251 in vitro; Fe3O4@Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice in vivo, and can be traced by MRI.The Fe3O4@Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma in vivo. |
url |
http://europepmc.org/articles/PMC5898739?pdf=render |
work_keys_str_mv |
AT yaoqige preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT yuejiaozhong preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT guozhongji preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT qianlinglu preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT xinyudai preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT zhiruiguo preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT pengzhang preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT gangpeng preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT kangzhenzhang preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma AT yuntaoli preparationandcharacterizationoffe3o4auc225compositetargetednanoparticlesformriofhumanglioma |
_version_ |
1725019050762829824 |