Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.

To study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics w...

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Main Authors: Yaoqi Ge, Yuejiao Zhong, Guozhong Ji, Qianling Lu, Xinyu Dai, Zhirui Guo, Peng Zhang, Gang Peng, Kangzhen Zhang, Yuntao Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5898739?pdf=render
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spelling doaj-220998a55f2d4113981efc5ef7b1c90e2020-11-25T01:46:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019570310.1371/journal.pone.0195703Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.Yaoqi GeYuejiao ZhongGuozhong JiQianling LuXinyu DaiZhirui GuoPeng ZhangGang PengKangzhen ZhangYuntao LiTo study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe3O4@Au-C225 composite targeted MNPs on U251 cells in vitro were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe3O4@Au-C225 composite targeted MNPs by MRI.The self-prepared Fe3O4@Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe3O4@Au-C225 composite targeted MNPs were prepared successfully. Fe3O4@Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251 in vitro; Fe3O4@Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice in vivo, and can be traced by MRI.The Fe3O4@Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma in vivo.http://europepmc.org/articles/PMC5898739?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yaoqi Ge
Yuejiao Zhong
Guozhong Ji
Qianling Lu
Xinyu Dai
Zhirui Guo
Peng Zhang
Gang Peng
Kangzhen Zhang
Yuntao Li
spellingShingle Yaoqi Ge
Yuejiao Zhong
Guozhong Ji
Qianling Lu
Xinyu Dai
Zhirui Guo
Peng Zhang
Gang Peng
Kangzhen Zhang
Yuntao Li
Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
PLoS ONE
author_facet Yaoqi Ge
Yuejiao Zhong
Guozhong Ji
Qianling Lu
Xinyu Dai
Zhirui Guo
Peng Zhang
Gang Peng
Kangzhen Zhang
Yuntao Li
author_sort Yaoqi Ge
title Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
title_short Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
title_full Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
title_fullStr Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
title_full_unstemmed Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.
title_sort preparation and characterization of fe3o4@au-c225 composite targeted nanoparticles for mri of human glioma.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description To study the characterization of Fe3O4@Au-C225 composite targeted MNPs.Fe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe3O4@Au-C225 composite targeted MNPs on U251 cells in vitro were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe3O4@Au-C225 composite targeted MNPs by MRI.The self-prepared Fe3O4@Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe3O4@Au-C225 composite targeted MNPs were prepared successfully. Fe3O4@Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251 in vitro; Fe3O4@Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice in vivo, and can be traced by MRI.The Fe3O4@Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma in vivo.
url http://europepmc.org/articles/PMC5898739?pdf=render
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