Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy

Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy

Dynamin 1 is a large neuron-specific GTPase involved in the endocytosis and recycling of pre-synaptic membranes and synaptic vesicles. Mutations in the gene encoding dynamin 1 (DNM1) underlie two epileptic encephalopathy syndromes, Lennox-Gastaut Syndrome and Infantile Spasms. Mice homozygous for th...

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Bibliographic Details
Main Authors: Samuel Asinof, Connie Mahaffey, Barbara Beyer, Wayne N. Frankel, Rebecca Boumil
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Dynamin
Alternative isoform
Epilepsy
Seizure
Endocytosis
Fitful
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301541

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