Site-directed mutagenesis of HIV-1 vpu gene demonstrates two clusters of replication-defective mutants with distinct ability to down-modulate cell surface CD4 and tetherin

Site-directed mutagenesis of HIV-1 vpu gene demonstrates two clusters of replication-defective mutants with distinct ability to down-modulate cell surface CD4 and tetherin

HIV-1 Vpu acts positively on viral infectivity by mediating CD4 degradation in endoplasmic reticulum and enhances virion release by counteracting a virion release restriction factor, tetherin. In order to define the impact of Vpu activity on HIV-1 replication, we have generated a series of site-spec...

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Bibliographic Details
Main Authors: Masako Nomaguchi, Naoya Doi, Sachi Fujiwara, Mikako Fujita, Akio Adachi
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-11-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
replication
Vpu
CD4
tetherin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00116/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00116/full

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