Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.

Bibliographic Details
Main Authors:	Miaoxing Wang, Xujun Han, Chuyan Liu, Rie Takayama, Tetsuo Yasugi, Shin-Ichiro Ei, Masaharu Nagayama, Yoshitaro Tanaka, Makoto Sato
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22442-3

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spelling	doaj-21ea5b007b2e48b5a7e21e0a8c15e3d02021-04-11T11:12:01ZengNature Publishing GroupNature Communications2041-17232021-04-0112111510.1038/s41467-021-22442-3Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brainMiaoxing Wang0Xujun Han1Chuyan Liu2Rie Takayama3Tetsuo Yasugi4Shin-Ichiro Ei5Masaharu Nagayama6Yoshitaro Tanaka7Makoto Sato8Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityLaboratory of Developmental Neurobiology, Graduate School of Medical Sciences, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityDepartment of Mathematics, Faculty of Science, Hokkaido UniversityResearch Institute for Electronic Science, Research Center of Mathematics for Social Creativity, Hokkaido UniversityDepartment of Complex and Intelligent Systems, School of Systems Information Science, Future University HakodateMathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa UniversityDuring Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.https://doi.org/10.1038/s41467-021-22442-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato
spellingShingle	Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain Nature Communications
author_facet	Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato
author_sort	Miaoxing Wang
title	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_short	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_full	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_fullStr	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_full_unstemmed	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_sort	intracellular trafficking of notch orchestrates temporal dynamics of notch activity in the fly brain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.
url	https://doi.org/10.1038/s41467-021-22442-3
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Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

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