| Summary: | <p class="Default">Laser photobiomodulation (LPBM) has been proposed as a multi-target (multi-hallmark) therapy for cancer and other complex diseases based on an approach that aims to substitute and/or complement metabolic energy pathways through oxygen-dependent (e.g., cytochrome c oxidase (CcO)) and/or oxygen-independent (e.g., light-water interactions (e.g., F0-F1 motors)) mechanisms with critical signaling pathways in primarily aqueous media. Cellular and molecular bases for water-mediated, long-range, energy supplementation aimed at inducing and modulating physiologically reparative processes, including apoptosis, have been previously presented through a mechanism termed Photo Infrared Pulsed Biomodulation (PIPBM). Water’s role as an oscillator in LPBM has also been documented. These ideas were recently complemented by integrating the role of the quasi-crystalline exclusion zone (EZ) described by Pollack as the fourth phase of water. This is retrospective analysis of experimental and clinical data using an infrared pulsed laser device (IPLD). It found photo-induced effects over the water dynamics of burned rat tissue monitored by <sup>1</sup>H-NMR transverse relaxation times (1/T2), indicating significantly greater structuring of water. In addition, a microdensitometry study of T2 weighted tumor heterogeneities from a phase I clinical trial of the IPLD in patients with advanced neoplasias and an algorithm for tumor characterization indicated significantly increased structuring of water, possibly proving a photobiomodulation effect over the EZ associated with histologically-confirmed selective photo-induced tumor cell death. To the best of our knowledge, this is the first clinical demonstration of light-induced effects over the EZ. It supports our premise that LPBM can increase potential energy in the EZ, which then acts as a rechargeable electrolytic bio-battery for the external selective supplementation of the energy demand required for cellular work, signaling pathways and gene expression in the presence of injury-induced redox potentials. It further suggests that EZ structuring may be used as a predicator of anticancer response before measurable tumor volume reduction.</p><p class="Default">------------------------------------------------</p><p class="Default"><strong>Cite this article as</strong>: Santana-Blank L, Rodriguez-Santana E, Reyes H, Santana- Rodriguez J, Santana- Rodriguez K. Water-light interaction: A novel pathway for multi hallmark therapy in cancer. <em>Int J Cancer Ther Oncol</em> 2014; <strong>2</strong>(1):02012.</p><p class="Default"><strong>DOI:</strong> <a href="http://dx.doi.org/10.14319/ijcto.0201.2" target="_blank">http://dx.doi.org/10.14319/ijcto.0201.2</a></p>
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