Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection

Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection

Even though immunoglobulins are critical for immune responses and human survival, the diversity of the immunoglobulin heavy chain gene (IGH) is poorly known and mostly characterized only by serological methods. Moreover, this genomic region is not well-covered in genomic databases and genome-wide as...

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Bibliographic Details
Main Authors: Verónica Calonga-Solís, Danielle Malheiros, Marcia Holsbach Beltrame, Luciana de Brito Vargas, Renata Montoro Dourado, Hellen Caroline Issler, Roseli Wassem, Maria Luiza Petzl-Erler, Danillo G. Augusto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
IGHG genes
immunoglobulin heavy chain
molecular characterization
genetic diversity
populations
DNA sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01161/full

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