A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with...

Full description

Bibliographic Details
Main Authors:	Luana A. Osório, Elisabete Silva, Ruth E. Mackay
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Bioengineering
Subjects:	organ-on-a-chip scaffold tissue engineering biomaterials additive manufacturing
Online Access:	https://www.mdpi.com/2306-5354/8/8/113

id	doaj-21d402627d3b46b789f99604c0cc5c4e
record_format	Article
spelling	doaj-21d402627d3b46b789f99604c0cc5c4e2021-08-26T13:31:56ZengMDPI AGBioengineering2306-53542021-08-01811311310.3390/bioengineering8080113A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) SystemsLuana A. Osório0Elisabete Silva1Ruth E. Mackay2Department of Mechanical, Aerospace and Civil Engineering, Brunel University London, Uxbridge UB8 3PH, UKDepartment of Life Science, Brunel University London, Uxbridge UB8 3PH, UKDepartment of Mechanical, Aerospace and Civil Engineering, Brunel University London, Uxbridge UB8 3PH, UKDrug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with results from later human clinical trials. Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems, which recapitulate the physiochemical environment of a specific organ by emulating the perfusion and shear stress cellular tissue undergoes in vivo and could replace current animal models. The success of culturing cells and cell-derived tissues within these systems is dependent on the scaffold chosen; hence, scaffolds are critical for the success of OOACs in research. A literature review was conducted looking at current OOAC systems to assess the advantages and disadvantages of different materials and manufacturing techniques used for scaffold production; and the alternatives that could be tailored from the macro tissue engineering research field.https://www.mdpi.com/2306-5354/8/8/113organ-on-a-chipscaffoldtissue engineeringbiomaterialsadditive manufacturing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Luana A. Osório Elisabete Silva Ruth E. Mackay
spellingShingle	Luana A. Osório Elisabete Silva Ruth E. Mackay A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems Bioengineering organ-on-a-chip scaffold tissue engineering biomaterials additive manufacturing
author_facet	Luana A. Osório Elisabete Silva Ruth E. Mackay
author_sort	Luana A. Osório
title	A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
title_short	A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
title_full	A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
title_fullStr	A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
title_full_unstemmed	A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
title_sort	review of biomaterials and scaffold fabrication for organ-on-a-chip (ooac) systems
publisher	MDPI AG
series	Bioengineering
issn	2306-5354
publishDate	2021-08-01
description	Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with results from later human clinical trials. Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems, which recapitulate the physiochemical environment of a specific organ by emulating the perfusion and shear stress cellular tissue undergoes in vivo and could replace current animal models. The success of culturing cells and cell-derived tissues within these systems is dependent on the scaffold chosen; hence, scaffolds are critical for the success of OOACs in research. A literature review was conducted looking at current OOAC systems to assess the advantages and disadvantages of different materials and manufacturing techniques used for scaffold production; and the alternatives that could be tailored from the macro tissue engineering research field.
topic	organ-on-a-chip scaffold tissue engineering biomaterials additive manufacturing
url	https://www.mdpi.com/2306-5354/8/8/113
work_keys_str_mv	AT luanaaosorio areviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems AT elisabetesilva areviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems AT ruthemackay areviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems AT luanaaosorio reviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems AT elisabetesilva reviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems AT ruthemackay reviewofbiomaterialsandscaffoldfabricationfororganonachipooacsystems
_version_	1721194890966073344

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Similar Items