Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum

Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum

Zolvix® is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug has been reported to produce hypercontraction of Cae...

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Bibliographic Details
Main Authors: Melanie Abongwa, Djordje S. Marjanovic, James G. Tipton, Fudan Zheng, Richard J. Martin, Sasa M. Trailovic, Alan P. Robertson
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320717301227

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