Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

Abstract Background Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVac (Vo), which elicited protective immunity against E. coli K1 infecti...

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Bibliographic Details
Main Authors: Jin Zhang, Hongwu Sun, Chen Gao, Ying Wang, Xin Cheng, Yun Yang, Qiang Gou, Langhuang Lei, Yanping Chen, Xingyong Wang, Quanming Zou, Jiang Gu
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Nanobiotechnology
Subjects:
Escherichia coli K1
Chitosan
PLGA
Nanoparticles
Vaccine
Online Access:https://doi.org/10.1186/s12951-021-00812-9

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