Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death

Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death

In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-spe...

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Bibliographic Details
Main Authors: Frederick J. Kohlhapp, Erica J. Huelsmann, Andrew T. Lacek, Jason M. Schenkel, Jevgenijs Lusciks, Joseph R. Broucek, Josef W. Goldufsky, Tasha Hughes, Janet P. Zayas, Hubert Dolubizno, Ryan T. Sowell, Regina Kühner, Sarah Burd, John C. Kubasiak, Arman Nabatiyan, Sh’Rae Marshall, Praveen K. Bommareddy, Shengguo Li, Jenna H. Newman, Claude E. Monken, Sasha H. Shafikhani, Amanda L. Marzo, Jose A. Guevara-Patino, Ahmed Lasfar, Paul G. Thomas, Edmund C. Lattime, Howard L. Kaufman, Andrew Zloza
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
cancer
infection
concomitant
melanoma
breast cancer
influenza
mouse
PD-1
CD8+ T cells
viral
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313249

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