Methylation and Transcripts Expression at the Imprinted GNAS Locus in Human Embryonic and Induced Pluripotent Stem Cells and Their Derivatives

Methylation and Transcripts Expression at the Imprinted GNAS Locus in Human Embryonic and Induced Pluripotent Stem Cells and Their Derivatives

Data from the literature indicate that genomic imprint marks are disturbed in human pluripotent stem cells (PSCs). GNAS is an imprinted locus that produces one biallelic (Gsα) and four monoallelic (NESP55, GNAS-AS1, XLsα, and A/B) transcripts due to differential methylation of their promoters (DMR)....

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Bibliographic Details
Main Authors: Virginie Grybek, Laetitia Aubry, Stéphanie Maupetit-Méhouas, Catherine Le Stunff, Cécile Denis, Mathilde Girard, Agnès Linglart, Caroline Silve
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111400232X

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http://www.sciencedirect.com/science/article/pii/S221367111400232X

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