Three-Color FISH Analysis of TMPRSS2/ERG Fusions in Prostate Cancer Indicates That Genomic Microdeletion of Chromosome 21 Is Associated with Rearrangement

Three-Color FISH Analysis of TMPRSS2/ERG Fusions in Prostate Cancer Indicates That Genomic Microdeletion of Chromosome 21 Is Associated with Rearrangement

The recent description of novel recurrent gene fusions in ~80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearr...

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Bibliographic Details
Main Authors: Maisa Yoshimoto, Anthony M. Joshua, Susan Chilton-MacNeill, Jane Bayani, Shamini Selvarajah, Andrew J. Evans, Maria Zielenska, Jeremy A. Squire
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TMPRSS2/ERG rearrangements
microhomology
genome architecture
FISH
genomic microdeletions
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800291

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http://www.sciencedirect.com/science/article/pii/S1476558606800291

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