The Impact of Normal Saline or Balanced Crystalloid on Plasma Chloride Concentration and Acute Kidney Injury in Patients With Predicted Severe Acute Pancreatitis: Protocol of a Phase II, Multicenter, Stepped-Wedge, Cluster-Randomized, Controlled Trial

The Impact of Normal Saline or Balanced Crystalloid on Plasma Chloride Concentration and Acute Kidney Injury in Patients With Predicted Severe Acute Pancreatitis: Protocol of a Phase II, Multicenter, Stepped-Wedge, Cluster-Randomized, Controlled Trial

Introduction/aim: The supraphysiologic chloride concentration of normal saline may contribute to acute kidney injury (AKI). Balanced crystalloids can decrease chloride concentration and AKI in critically ill patients. We aim to test the hypothesis that, in patients with predicted severe acute pancre...

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Bibliographic Details
Main Authors: Bo Ye, Mingfeng Huang, Tao Chen, Gordon Doig, Bin Wu, Mingzhi Chen, Shumin Tu, Xiaomei Chen, Mei Yang, Guoxiu Zhang, Qiang Li, Xinting Pan, Lijuan Zhao, Honghai Xia, Yan Chen, Lu Ke, Zhihui Tong, Rinaldo Bellomo, John Windsor, Weiqin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
acute pancreatitis
saline
crystalloid
acute kidney injury
intravenous fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.731955/full

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