Mitoprotective effect of the receptor antagonist interleukin-1 in experimental cerebral stroke
Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats. Against a background of RAIL-1 administration significant stabilization of mitochondria...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2012-12-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/17019/14706 |
| Summary: | Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats. Against a background of RAIL-1 administration significant stabilization of mitochondria functional activity was noted (by blocking of mitochondrial pore opening) as wel as the state of thiol-disulfide system: normalization of activity of glutationperoxidase and glutationreductase, increase of levels of reduced forms of glutathione and thiols against a background of reduction of their oxidized forms. By mitochondrial activity RAIL-1 can be compared to Thiotriazoline and even exceeds it in some parameters.
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| ISSN: | 2306-8027 2310-1237 |