Promoter analysis of the DHCR24 (3β-hydroxysterol Δ24-reductase) gene: characterization of SREBP (sterol-regulatoryelement-binding protein)-mediated activation

Promoter analysis of the DHCR24 (3β-hydroxysterol Δ24-reductase) gene: characterization of SREBP (sterol-regulatoryelement-binding protein)-mediated activation

DHCR24 (3β-hydroxysterol Δ24-reductase) catalyses the reduction of the C-24 double bond of sterol intermediates during cholesterol biosynthesis. DHCR24 has also been involved in cell growth, senescence and cellular response to oncogenic and oxidative stress. Despite its importa...

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Bibliographic Details
Main Authors: Lidia A. Daimiel, María E. Fernández‑Suárez, Sara Rodríguez‑Acebes, Lorena Crespo, Miguel A. Lasunción, Diego Gómez‑Coronado, Javier Martínez‑Botas
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2012-12-01
Series:Bioscience Reports
Subjects:
androgen
cholesterol
3β-hydroxysterol Δ24-reductase (DHCR24)
Krüppel-like factor 5 (KLF5)
promoter analysis
sterol-regulatory-element-binding protein (SREBP)
Online Access:http://www.bioscirep.org/bsr/033/e006/bsr033e006.htm

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