Revisiting the role of Dcc in visual system development with a novel eye clearing method

Revisiting the role of Dcc in visual system development with a novel eye clearing method

The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. Whilst Dcc is expressed postnatally in the eye, its function remains unknown as Dcc knockouts die at birth. To circumvent this drawback, we generated an eye-specific Dcc mutant. To study the organiza...

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Bibliographic Details
Main Authors:	Robin J Vigouroux, Quénol Cesar, Alain Chédotal, Kim Tuyen Nguyen-Ba-Charvet
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-02-01
Series:	eLife
Subjects:	retinal development retinal degeneration visual development axon guidance light sheet microscopy tissue clearing
Online Access:	https://elifesciences.org/articles/51275

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