Clinical role of serum Copeptin in acute coronary syndrome

Clinical role of serum Copeptin in acute coronary syndrome

Objective: To assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period. Subjects and methods: This study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in...

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Main Authors: Manal Abd El Baky Mahmoud, Menat Allah Ali Shaaban, Ali Ali Ramzy
Format: Article
Language:English
Published: SpringerOpen 2018-09-01
Series:The Egyptian Heart Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1110260818300486
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spelling doaj-217c935e4ff446caa2c2e4c69b58278b2020-11-25T02:55:48ZengSpringerOpenThe Egyptian Heart Journal1110-26082018-09-01703155159Clinical role of serum Copeptin in acute coronary syndromeManal Abd El Baky Mahmoud0Menat Allah Ali Shaaban1Ali Ali Ramzy2Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Egypt; Corresponding author.Department of Cardiology, Faculty of Medicine, Al Azhar University, EgyptObjective: To assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period. Subjects and methods: This study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in addition to 10 subjects serving as a healthy control group. Blood samples were collected for determination of CK-MB, cTnI and Copeptin. These were measured twice (in patients’ group); at 3 h and then at 6–9 h from admission time. Results: The first sample revealed a non-significant difference between UA group and AMI group as regards CKMB and troponin, however, high significant difference was found as regards Copeptin (Z = 5.29, P < 0.001). Moreover, ROC curve analysis of serum Copeptin for discriminating AMI group from UA group in the first sample showed diagnostic sensitivity and specificity of 100%. In conclusion: Determination of copeptin in early diagnosis of AMI has diagnostic value being superior to a conventional cTn-I within the first three hours after acute chest pain. Keywords: Copeptin, Acute coronary syndromehttp://www.sciencedirect.com/science/article/pii/S1110260818300486
collection DOAJ
language English
format Article
sources DOAJ
author Manal Abd El Baky Mahmoud
Menat Allah Ali Shaaban
Ali Ali Ramzy
spellingShingle Manal Abd El Baky Mahmoud
Menat Allah Ali Shaaban
Ali Ali Ramzy
Clinical role of serum Copeptin in acute coronary syndrome
The Egyptian Heart Journal
author_facet Manal Abd El Baky Mahmoud
Menat Allah Ali Shaaban
Ali Ali Ramzy
author_sort Manal Abd El Baky Mahmoud
title Clinical role of serum Copeptin in acute coronary syndrome
title_short Clinical role of serum Copeptin in acute coronary syndrome
title_full Clinical role of serum Copeptin in acute coronary syndrome
title_fullStr Clinical role of serum Copeptin in acute coronary syndrome
title_full_unstemmed Clinical role of serum Copeptin in acute coronary syndrome
title_sort clinical role of serum copeptin in acute coronary syndrome
publisher SpringerOpen
series The Egyptian Heart Journal
issn 1110-2608
publishDate 2018-09-01
description Objective: To assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period. Subjects and methods: This study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in addition to 10 subjects serving as a healthy control group. Blood samples were collected for determination of CK-MB, cTnI and Copeptin. These were measured twice (in patients’ group); at 3 h and then at 6–9 h from admission time. Results: The first sample revealed a non-significant difference between UA group and AMI group as regards CKMB and troponin, however, high significant difference was found as regards Copeptin (Z = 5.29, P < 0.001). Moreover, ROC curve analysis of serum Copeptin for discriminating AMI group from UA group in the first sample showed diagnostic sensitivity and specificity of 100%. In conclusion: Determination of copeptin in early diagnosis of AMI has diagnostic value being superior to a conventional cTn-I within the first three hours after acute chest pain. Keywords: Copeptin, Acute coronary syndrome
url http://www.sciencedirect.com/science/article/pii/S1110260818300486
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