A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.

Bibliographic Details
Main Authors: Bethany A. Weigele, Robert C. Orchard, Alyssa Jimenez, Gregory W. Cox, Neal M. Alto
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00700-7
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spelling doaj-217bfd32a26b4c0bb9b8f8ae3db9c3fe2021-05-11T07:55:43ZengNature Publishing GroupNature Communications2041-17232017-09-018111410.1038/s41467-017-00700-7A systematic exploration of the interactions between bacterial effector proteins and host cell membranesBethany A. Weigele0Robert C. Orchard1Alyssa Jimenez2Gregory W. Cox3Neal M. Alto4Department of Microbiology, University of Texas Southwestern Medical CenterDepartment of Pathology and Immunology, Washington University School of MedicineDepartment of Microbiology, University of Texas Southwestern Medical CenterDepartment of Microbiology, University of Texas Southwestern Medical CenterDepartment of Microbiology, University of Texas Southwestern Medical CenterMicrobial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.https://doi.org/10.1038/s41467-017-00700-7
collection DOAJ
language English
format Article
sources DOAJ
author Bethany A. Weigele
Robert C. Orchard
Alyssa Jimenez
Gregory W. Cox
Neal M. Alto
spellingShingle Bethany A. Weigele
Robert C. Orchard
Alyssa Jimenez
Gregory W. Cox
Neal M. Alto
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
Nature Communications
author_facet Bethany A. Weigele
Robert C. Orchard
Alyssa Jimenez
Gregory W. Cox
Neal M. Alto
author_sort Bethany A. Weigele
title A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
title_short A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
title_full A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
title_fullStr A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
title_full_unstemmed A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
title_sort systematic exploration of the interactions between bacterial effector proteins and host cell membranes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.
url https://doi.org/10.1038/s41467-017-00700-7
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