A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.

Bibliographic Details
Main Authors: Bethany A. Weigele, Robert C. Orchard, Alyssa Jimenez, Gregory W. Cox, Neal M. Alto
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00700-7
Description
Summary:Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.
ISSN:2041-1723