A High-Density Map for Navigating the Human Polycomb Complexome

A High-Density Map for Navigating the Human Polycomb Complexome

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome using a robust affinity purification mass spectrometry approach. Our high-density protein interaction network uncovered a diverse...

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Bibliographic Details
Main Authors: Simon Hauri, Federico Comoglio, Makiko Seimiya, Moritz Gerstung, Timo Glatter, Klaus Hansen, Ruedi Aebersold, Renato Paro, Matthias Gstaiger, Christian Beisel
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
Polycomb
gene silencing
AP-MS
proteomics
epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312098

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716312098

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