Glucagon receptor antagonism induces increased cholesterol absorption[S]

Glucagon receptor antagonism induces increased cholesterol absorption[S]

Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor (GCGR) antagonism has been proposed as a pharmacol...

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Bibliographic Details
Main Authors: Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
diabetes
glucagon receptor antagonist
cholesterol/absorption
hypercholesterolemia
glucagon-like peptide 2
bile acids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354870

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http://www.sciencedirect.com/science/article/pii/S0022227520354870

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