Highly efficient RNA-guided base editing in rabbit

Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-G...

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Main Authors:	Zhiquan Liu, Mao Chen, Siyu Chen, Jichao Deng, Yuning Song, Liangxue Lai, Zhanjun Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05232-2

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record_format	Article
spelling	doaj-216e4fab831c49e88ba047feee8413172021-05-11T09:29:03ZengNature Publishing GroupNature Communications2041-17232018-07-019111010.1038/s41467-018-05232-2Highly efficient RNA-guided base editing in rabbitZhiquan Liu0Mao Chen1Siyu Chen2Jichao Deng3Yuning Song4Liangxue Lai5Zhanjun Li6Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityJilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin UniversityBase editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.https://doi.org/10.1038/s41467-018-05232-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhiquan Liu Mao Chen Siyu Chen Jichao Deng Yuning Song Liangxue Lai Zhanjun Li
spellingShingle	Zhiquan Liu Mao Chen Siyu Chen Jichao Deng Yuning Song Liangxue Lai Zhanjun Li Highly efficient RNA-guided base editing in rabbit Nature Communications
author_facet	Zhiquan Liu Mao Chen Siyu Chen Jichao Deng Yuning Song Liangxue Lai Zhanjun Li
author_sort	Zhiquan Liu
title	Highly efficient RNA-guided base editing in rabbit
title_short	Highly efficient RNA-guided base editing in rabbit
title_full	Highly efficient RNA-guided base editing in rabbit
title_fullStr	Highly efficient RNA-guided base editing in rabbit
title_full_unstemmed	Highly efficient RNA-guided base editing in rabbit
title_sort	highly efficient rna-guided base editing in rabbit
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.
url	https://doi.org/10.1038/s41467-018-05232-2
work_keys_str_mv	AT zhiquanliu highlyefficientrnaguidedbaseeditinginrabbit AT maochen highlyefficientrnaguidedbaseeditinginrabbit AT siyuchen highlyefficientrnaguidedbaseeditinginrabbit AT jichaodeng highlyefficientrnaguidedbaseeditinginrabbit AT yuningsong highlyefficientrnaguidedbaseeditinginrabbit AT liangxuelai highlyefficientrnaguidedbaseeditinginrabbit AT zhanjunli highlyefficientrnaguidedbaseeditinginrabbit
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Highly efficient RNA-guided base editing in rabbit

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