Angiopoietin-like proteins: a comprehensive look

Angiopoietin-like proteins: a comprehensive look

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8. Emerging evidence implied a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological proc...

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Bibliographic Details
Main Author: Gaetano eSantulli
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Endocrinology
Subjects:
Hematopoietic Stem Cells
Inflammation
Insulin
Metabolism
Cancer
review
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00004/full
Description
Summary:Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8. Emerging evidence implied a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPLT.
ISSN:1664-2392

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