Nano-TiO2 an Efficient, Clean and Eco-friendly Catalyst for Synthesis of Naphthoxazinone Derivatives as High Potent Antibacterial Agents
Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1,2-dihydro-1-phenylnaphtho[1,2-e][1,3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of...
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| Format: | Article |
| Language: | English |
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Islamic Azad University
2018-12-01
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| Series: | Journal of Chemical Health Risks |
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| Online Access: | http://www.jchr.org/article_544457_8ef431aae84de6273f04a55c8567a268.pdf |
| Summary: | Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1,2-dihydro-1-phenylnaphtho[1,2-e][1,3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of nano-titanium oxide as solid, recyclable catalyst at one-pot and solvent-free conditions. These synthetic compounds 2a-e were evaluated as potential antibacterial agents. The structures of products were confirmed by spectral analysis FT-IR and <sup>1</sup>H NMR. The antibacterial activity of the compounds was screened against <em>Staphylococcus aureus </em>and <em>Escherichia coli.</em> These results showed that these compounds exhibited significant to moderate activities against both Gram (+) and Gram (-) organisms. |
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| ISSN: | 2251-6719 2251-6727 |