The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development.

The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development.

Cofilin is an essential actin remodeling protein promoting depolymerization and severing of actin filaments. To address the relevance of cofilin for the development and function of T cells in vivo, we generated knock-in mice in which T-cell-specific nonfunctional (nf) cofilin was expressed instead o...

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Bibliographic Details
Main Authors: Isabel Seeland, Ying Xiong, Christian Orlik, Daniel Deibel, Sandra Prokosch, Günter Küblbeck, Beate Jahraus, Daniela De Stefano, Sonja Moos, Florian C Kurschus, Bernd Arnold, Yvonne Samstag
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005380

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