In Situ Conversion of Melanoma Lesions into Autologous Vaccine by Intratumoral Injections of α-gal Glycolipids

In Situ Conversion of Melanoma Lesions into Autologous Vaccine by Intratumoral Injections of α-gal Glycolipids

Autologous melanoma associated antigens (MAA) on murine melanoma cells can elicit a protective anti-tumor immune response following a variety of vaccine strategies. Most require effective uptake by antigen presenting cells (APC). APC transport and process internalized MAA for activation of anti-tumo...

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Bibliographic Details
Main Authors: Uri Galili, Mark R. Albertini, Paul M. Sondel, Kim Wigglesworth, Mary Sullivan, Giles F. Whalen
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Cancers
Subjects:
Melanoma immunotherapy
anti-Gal antibody
α-gal glycolipids
α1,3-galactosyltransferase
Fcγ receptors
antigen presenting cells
Online Access:http://www.mdpi.com/2072-6694/2/2/773/

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http://www.mdpi.com/2072-6694/2/2/773/

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