Tumor mutational signatures in sebaceous skin lesions from individuals with Lynch syndrome

Tumor mutational signatures in sebaceous skin lesions from individuals with Lynch syndrome

Abstract Background Muir‐Torre syndrome is defined by the development of sebaceous skin lesions in individuals who carry a germline mismatch repair (MMR) gene mutation. Loss of expression of MMR proteins is frequently observed in sebaceous skin lesions, but MMR‐deficiency alone is not diagnostic for...

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Bibliographic Details
Main Authors: Peter Georgeson, Michael D. Walsh, Mark Clendenning, Simin Daneshvar, Bernard J. Pope, Khalid Mahmood, Jihoon E. Joo, Harindra Jayasekara, Mark A. Jenkins, Ingrid M. Winship, Daniel D. Buchanan
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Lynch syndrome
mismatch repair deficiency
mismatch repair immunohistochemistry
Muir‐Torre syndrome
sebaceoma
sebaceous adenoma
Online Access:https://doi.org/10.1002/mgg3.781

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