Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability

Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability

Histone H2AX plays a crucial role in molecular and cellular responses to DNA damage and in the maintenance of genome stability. It is downstream of ataxia telangiectasia mutated (ATM) damage signaling pathway and there is an emerging role of the transcription factor FoxO3a, a regulator of a variety...

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Bibliographic Details
Main Authors: Stephane Tarrade, Tanya Bhardwaj, Matthew Flegal, Lindsey Bertrand, Ilya Velegzhaninov, Alexey Moskalev, Dmitry Klokov
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
H2AX
FoxO3a
ionizing radiation
stress response
DNA damage signaling
genome stability
Online Access:http://www.mdpi.com/1422-0067/16/12/26216

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