Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural...
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Bibliographic Details
| Main Authors: |
Bikshapathi Jagga,
Megan Edwards,
Miriam Pagin,
Kylie M. Wagstaff,
David Aragão,
Noelia Roman,
Jeffrey D. Nanson,
Shane R. Raidal,
Nicole Dominado,
Murray Stewart,
David A. Jans,
Gary R. Hime,
Silvia K. Nicolis,
Christopher F. Basler,
Jade K. Forwood |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-20194-0
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