Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema.

Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema.

To describe the progression of parenchymal remodeling and metalloproteinases gene expression in earlier stages of emphysema, mice received porcine pancreatic elastase (PPE) instillation and Control groups received saline solution. After PPE instillation (1, 3, 6 hours, 3 and 21 days) we measured the...

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Main Authors: Fabíola S Z Robertoni, Clarice R Olivo, Juliana D Lourenço, Natália G Gonçalves, Ana Paula P Velosa, Chin J Lin, Cláudia M Fló, Beatriz M Saraiva-Romanholo, Sérgio D Sasaki, Milton A Martins, Walcy R Teodoro, Fernanda Degobbi T Q S Lopes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0129590

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