Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells

Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells

We examined the effect of etomoxir treatment on de novo cardiolipin (CL) biosynthesis in H9c2 cardiac myoblast cells. Etomoxir treatment did not affect the activities of the CL biosynthetic and remodeling enzymes but caused a reduction in [1-14C]palmitic acid or [1-14C]oleic acid incorporation into...

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Bibliographic Details
Main Authors: Fred Y. Xu, William A. Taylor, Jeffrey A. Hurd, Grant M. Hatch
Format: Article
Language:English
Published: Elsevier 2003-02-01
Series:Journal of Lipid Research
Subjects:
heart cells
mitochondria
phospholipids
glycerol kinase
1,2-diacyl-sn-glycerol acyltransferase
phosphatidate phosphohydrolase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312293

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