PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

Abstract Background The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is uncle...

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Bibliographic Details
Main Authors: Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Yu Ri Kim, Jin Seok Kim, June-Won Cheong, Yoo Hong Min
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Leukemia stem cells
G9a
PERK/NRF2
Autophagy
Resistance
Online Access:http://link.springer.com/article/10.1186/s13046-020-01565-3

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