| Summary: | Objective: To investigate the influence of factors such as age, gender and pre-operative behavior rating on the outcome of sedation using oral trimeprazine during dental treatment of children. Method: Records of children who received dental treatment under sedation with oral trimeprazine between 2000 and 2007 were reviewed and the following data were obtained: age and weight of patient at the time of treatment, gender, behavior classification prior to sedation, dose of medication used, efficacy of sedation and treatment accomplished. Descriptive statistics, cross-tabulations and χ2 analysis were done. Result: Forty-eight sedation sessions met the inclusive criteria for children whose mean age was 4.92 (SD 1.65, range 3.0–8.0) years and mean weight was 18.23 (SD 4.82, range: 12.0–31.0) kg. Overall, 54.2% (26/48) of the sedations were rated successful, 20.8% (10/48) were partially successful and 25.0% (12/48) not successful. Younger children 3–5 years, and those with only negative pre-operative behavior rating had more successful sedation sessions than older, 6–8 years or children with definitely negative pre-operative behavior rating (X2 = 8.165, p = .017) and (X2 = 17.258, p = .001), respectively. Conclusion: Variables such as patient’s age and pre-operative behavior but not gender and type of treatment could predict outcome of dental sedation using trimeprazine in children. Keywords: Sedation, Antihistamine, Oral trimeprazine, Oral sedation, Children
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