O-glycosylation in cell wall proteins in Scedosporium prolificans is critical for phagocytosis and inflammatory cytokines production by macrophages.

O-glycosylation in cell wall proteins in Scedosporium prolificans is critical for phagocytosis and inflammatory cytokines production by macrophages.

In this study, we analyze the importance of O-linked oligosaccharides present in peptidorhamnomannan (PRM) from the cell wall of the fungus Scedosporium prolificans for recognition and phagocytosis of conidia by macrophages. Adding PRM led to a dose-dependent inhibition of conidia phagocytosis, wher...

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Bibliographic Details
Main Authors: Mariana I D S Xisto, Vera C B Bittencourt, Livia Cristina Liporagi-Lopes, Rosa M T Haido, Morena S A Mendonça, Guilherme Sassaki, Rodrigo T Figueiredo, Maria Teresa V Romanos, Eliana Barreto-Bergter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4396840?pdf=render

Internet

http://europepmc.org/articles/PMC4396840?pdf=render

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