Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Here, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.

Bibliographic Details
Main Authors:	Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, John L. Rubinstein, Bebhinn Treanor, Jean-Philippe Julien
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23825-2

id	doaj-21239c53aca444dbbc85f54151271ca5
record_format	Article
spelling	doaj-21239c53aca444dbbc85f54151271ca52021-06-20T11:13:41ZengNature Publishing GroupNature Communications2041-17232021-06-0112111210.1038/s41467-021-23825-2Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizersEdurne Rujas0Iga Kucharska1Yong Zi Tan2Samir Benlekbir3Hong Cui4Tiantian Zhao5Gregory A. Wasney6Patrick Budylowski7Furkan Guvenc8Jocelyn C. Newton9Taylor Sicard10Anthony Semesi11Krithika Muthuraman12Amy Nouanesengsy13Clare Burn Aschner14Katherine Prieto15Stephanie A. Bueler16Sawsan Youssef17Sindy Liao-Chan18Jacob Glanville19Natasha Christie-Holmes20Samira Mubareka21Scott D. Gray-Owen22John L. Rubinstein23Bebhinn Treanor24Jean-Philippe Julien25Program in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteDepartment of Immunology, University of TorontoProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteCombined Containment Level 3 Unit, University of TorontoCombined Containment Level 3 Unit, University of TorontoProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteDistributed BioDistributed BioDistributed BioCombined Containment Level 3 Unit, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Molecular Genetics, University of TorontoProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteDepartment of Immunology, University of TorontoProgram in Molecular Medicine, The Hospital for Sick Children Research InstituteHere, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.https://doi.org/10.1038/s41467-021-23825-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Edurne Rujas Iga Kucharska Yong Zi Tan Samir Benlekbir Hong Cui Tiantian Zhao Gregory A. Wasney Patrick Budylowski Furkan Guvenc Jocelyn C. Newton Taylor Sicard Anthony Semesi Krithika Muthuraman Amy Nouanesengsy Clare Burn Aschner Katherine Prieto Stephanie A. Bueler Sawsan Youssef Sindy Liao-Chan Jacob Glanville Natasha Christie-Holmes Samira Mubareka Scott D. Gray-Owen John L. Rubinstein Bebhinn Treanor Jean-Philippe Julien
spellingShingle	Edurne Rujas Iga Kucharska Yong Zi Tan Samir Benlekbir Hong Cui Tiantian Zhao Gregory A. Wasney Patrick Budylowski Furkan Guvenc Jocelyn C. Newton Taylor Sicard Anthony Semesi Krithika Muthuraman Amy Nouanesengsy Clare Burn Aschner Katherine Prieto Stephanie A. Bueler Sawsan Youssef Sindy Liao-Chan Jacob Glanville Natasha Christie-Holmes Samira Mubareka Scott D. Gray-Owen John L. Rubinstein Bebhinn Treanor Jean-Philippe Julien Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers Nature Communications
author_facet	Edurne Rujas Iga Kucharska Yong Zi Tan Samir Benlekbir Hong Cui Tiantian Zhao Gregory A. Wasney Patrick Budylowski Furkan Guvenc Jocelyn C. Newton Taylor Sicard Anthony Semesi Krithika Muthuraman Amy Nouanesengsy Clare Burn Aschner Katherine Prieto Stephanie A. Bueler Sawsan Youssef Sindy Liao-Chan Jacob Glanville Natasha Christie-Holmes Samira Mubareka Scott D. Gray-Owen John L. Rubinstein Bebhinn Treanor Jean-Philippe Julien
author_sort	Edurne Rujas
title	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
title_short	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
title_full	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
title_fullStr	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
title_full_unstemmed	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
title_sort	multivalency transforms sars-cov-2 antibodies into ultrapotent neutralizers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Here, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.
url	https://doi.org/10.1038/s41467-021-23825-2
work_keys_str_mv	AT edurnerujas multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT igakucharska multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT yongzitan multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT samirbenlekbir multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT hongcui multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT tiantianzhao multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT gregoryawasney multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT patrickbudylowski multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT furkanguvenc multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT jocelyncnewton multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT taylorsicard multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT anthonysemesi multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT krithikamuthuraman multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT amynouanesengsy multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT clareburnaschner multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT katherineprieto multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT stephanieabueler multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT sawsanyoussef multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT sindyliaochan multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT jacobglanville multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT natashachristieholmes multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT samiramubareka multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT scottdgrayowen multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT johnlrubinstein multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT bebhinntreanor multivalencytransformssarscov2antibodiesintoultrapotentneutralizers AT jeanphilippejulien multivalencytransformssarscov2antibodiesintoultrapotentneutralizers
_version_	1721370304845971456

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Similar Items