CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

Sanitization of nucleotide pools is essential for genome maintenance. Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) is a key enzyme in this pathway since it catalyzes the cleavage of 2′-deoxyuridine 5′-triphosphate (dUTP) into 2′-deoxyuridine 5&am...

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Bibliographic Details
Main Authors: Hajnalka Laura Pálinkás, Gergely Attila Rácz, Zoltán Gál, Orsolya Ivett Hoffmann, Gergely Tihanyi, Gergely Róna, Elen Gócza, László Hiripi, Beáta G. Vértessy
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
dUTPase
CRISPR/Cas9-mediated knock-out
blastocyst outgrowth
embryonic development
Online Access:https://www.mdpi.com/2218-273X/9/4/136

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